The dose–effect relationship of baclofen in alcohol dependence: A 1‐year cohort study (Human Psychopharmacology, 2017)
Autoren: Baptiste Pignon, Julien Labreuche, Marine Auffret, Sophie Gautier, Sylvie Deheul, Nicolas Simioni, Olivier Cottencin, Régis Bordet, Alain Duhamel & Benjamin Rolland
(pp, 05.01.2020)
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Abstract im englischen Original
Objective: Our aim is to study the relationship between dose of baclofen and effectiveness in alcohol dependence.
Methods: Two hundred two patients with alcohol dependence, who received baclofen treatment for drinking reduction, were followed up for 1 year. For each patient‐month of treatment, the maximum daily dose of baclofen (DDB) and average weekly alcohol consumption (AWAC) were calculated. We defined a favorable drinking outcome as an AWAC under 200 g/w for at least 2 consecutive months. We divided the DDB of each patient‐month into 3 categories (low dose: <90 mg/d, medium dose: 90–150 mg/d, and high dose: >150 mg/d) and investigated the relationship between reaching a favorable outcome and the concurrent DDB category in a time‐varying Cox regression analysis. Hazard ratios (HRs) were adjusted based on age, sex, and initial AWAC.
Results: One hundred forty subjects were followed during at least 1 month. Of these patients, 58 (41%) had a favorable drinking outcome. In comparison to low dose, medium dose was associated with a decreased rate of favorable drinking outcome (HR = 0.42; 95% CI [0.20, 0.88]), whereas no difference was found with high dose (HR = 1.31; 95% CI [0.65, 2.64]).
Conclusion: The relationship between dose of baclofen and favorable drinking outcome was U‐shaped, that is, was increased at low and high doses compared to medium doses.
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