High-Dose Baclofen for Treatment-Resistant Alcohol Dependence (Journal of Clinical Psychopharmacology, 2012)
Autoren: Adam Pastor, David M. L. Jones & Jon Currie
(pp, 11.10.2014)
Struktur des Inhalts
Abstract im englischen Original
Alcohol dependence is associated with a wide array of physical and psychiatric complications and is a major cause of morbidity and mortality worldwide. Recent randomized trials of baclofen, with a total daily dose 30 mg administered in 3 divided doses, have supported its efficacy in reducing craving and promoting abstinence from alcohol. Individual case studies support a possible increased effect at higher doses for treatment-resistant patients. Here, we report on 4 alcohol-dependent patients resistant to standard treatments who responded to higher doses of baclofen ranging from 75 to 125 mg daily. Further research into the use of high-dose baclofen for treatment-resistant alcohol dependence is warranted.
Link zum englischen Abstract
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Im Zuge dieses Artikels gab es zwischen den Autoren Adam Pastor, David M. L. Jones & Jon Currie und Benjamin Rolland, Régis Bordet, Sylvie Deheul & Olivier Cottencin 2013 einen Austausch im Journal of Clinical Psychopharmacology (Apr;33(2):280-282), den Sie auf Anfrage ebenfalls gerne einsehen können.
