Die Rolle des GABA-B-Rezeptor-Systems bei Alkoholabhängigkeit und Stress mit Schwerpunkt auf klinischen Studien und Behandlungsperspektiven (Alcohol, 2009)

Role of the GABA_B receptor system in alcoholism and stress: focus on clinical studies and treatment perspectives (Alcohol, 2009)
Autoren: Giovanni Addolorato, Lorenzo Leggio, Silvia Cardoneu, Anna Ferruli & Giovanni Gasbarrini
(pp, 05.12.2014)

Abstract im englischen Original

Alcoholism and stress share some common neurobiological circuits, including the GABAergic system. In particular, the GABA_B receptor seems to play an important role. The GABA_B receptor agonist baclofen has been studied as a treatment for alcohol-dependent subjects. Baclofen administration in alcohol-dependent patients was able to promote abstinence, inducing the remission of withdrawal symptoms, reducing alcohol craving, and reducing alcohol intake. Baclofen also reduced anxiety in alcohol-dependent subjects, probably acting on brain stress circuitry and/or on other neuroendocrine systems. Baclofen also showed excellent safety and tolerability, even in alcohol-dependent patients with advanced liver disease (i.e. cirrhosis). Future studies should investigate which alcoholic subtype may better benefit of the administration of baclofen in the treatment of alcohol dependence.

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