Eine Kohortenstudie mit Baclofen zur Untersuchung der Alkoholabstinenz bei Patienten mit Lebererkrankung (Alcohol 2017)

A prospective cohort study examining the effectiveness of baclofen in the maintenance of abstinence in alcohol use disorder patients attending a joint liver and alcohol treatment clinic, Alcohol (2017)
Autoren: Owens L., Thompson A., Rose A., Gilmore I., Pirmohamed M. , Richardson P.
(pn, 15.05.2017)

Abstract im englischen Original:

Alcohol-related liver disease (ARLD) is the leading cause of alcohol-related mortality in the UK. Helping patients with ARLD to stop drinking is an important treatment goal. The aim of this study is to explore baclofen’s utility in maintaining abstinence.

A prospective cohort study: Patients with ARLD were commenced on baclofen; the dose was titrated according to tolerability and response up to 30 mg three times daily. Severity of physical dependence and biochemical markers of liver injury were assessed at baseline, 3 months, and 12 months.

Length of follow-up differed. Of 219 patients in the original cohort, 186 and 113 were evaluated at 3 months and 12 months, respectively. Loss to follow-up was due to death, baclofen non-adherence, and failure to attend appointments. Comparison of baseline and 1-year biochemical markers showed significant reductions in GGT (median change = 82.0; 95% CI = −149.0 to −40.0; p < 0.0005), ALT (−10.5; 95% CI = −16.5 to −5.0; p = 0.001), and bilirubin (−4.5; 95% CI = −7.0 to −2.0; p < 0.001). The proportion of eligible patients reporting complete abstinence at 3 and 12 months was 55% and 53%, respectively. A significant reduction in alcohol consumption and Severity of Alcohol Dependence Questionnaire score was observed at both follow-up time points.

Adherence to the baclofen was good, and it had a positive impact on measures of alcohol consumption. A limitation of our study is its observational nature. Further randomized studies alongside investigation of dosing strategies are required.

· Liver function tests generally improved over the observational period.
· Patients reporting complete abstinence at 3 and 12 months were 55% and 53%, respectively.
· Dosing strategies for baclofen in this population require further investigation.

Keywords: baclofen, alcohol-use disorder, alcohol-related liver disease

Link zum englischen Abstract
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